Sussex Formulary

Drug Status Key

  • Non-Specialist Drugs
  • Specialist recommendation (or initiation where noted)
  • Specialist Initiation WITH Shared Care Guidelines
  • Specialist ONLY Drugs
  • Mixed Status - See individual drug entries for more details

Preferences

  • First Line
  • Second Line
  • Third Line
  • No Preference

Alemtuzumab

Black Triangle { Value = MHRA Warning Exists, Index = 4 } { Value = NICE, Index = 0 } { Value = EMC, Index = 3 }

Cladribine

{ Value = NICE, Index = 0 } { Value = EMC, Index = 3 }

Cladribine 10mg tablets

Pack
4 tablet
1 tablet
6 tablet

Dimethyl fumarate

{ Value = MHRA Warning Exists, Index = 4 } { Value = BLUETEQ, Index = 5 } { Value = NICE, Index = 0 } { Value = EMC, Index = 3 }
Commissioned by NHSE

Dimethyl fumarate 30mg gastro-resistant tablets

Pack
42 tablet
210 tablet

Dimethyl fumarate 120mg gastro-resistant tablets

Pack
90 tablet
180 tablet

Dimethyl fumarate 120mg gastro-resistant capsules

Pack
14 capsule
56 capsule

Dimethyl fumarate 240mg gastro-resistant capsules

Pack
56 capsule

Skilarence 30mg gastro-resistant tablets

Pack
42 tablet (3 x 14 tablets)
210 tablet

Skilarence 120mg gastro-resistant tablets

Pack
90 tablet (6 x 15 tablets)
180 tablet (9 x 20 tablets)

Tecfidera 120mg gastro-resistant capsules

Pack
14 capsule

Tecfidera 240mg gastro-resistant capsules

Pack
56 capsule (2 x 28 capsules)

Fingolimod

Black Triangle { Value = NICE, Index = 0 } { Value = EMC, Index = 3 }

Commissioned by NHSE

Fingolimod 250microgram capsules

Pack
28 capsule

Fingolimod 500microgram capsules

Pack
7 capsule
28 capsule

Gilenya 0.25mg capsules

Pack
28 capsule (2 x 14 capsules)

Gilenya 0.5mg capsules

Pack
28 capsule (2 x 14 capsules)
7 capsule

Glatiramer

{ Value = NICE, Index = 0 } { Value = EMC, Index = 3 }

Interferon beta-1a

{ Value = NICE, Index = 0 } { Value = EMC, Index = 3 }

Avonex 30micrograms/0.5ml

Pack
4 pre-filled disposable injection
12 pre-filled disposable injection

Rebif 8.8micrograms/0.2ml

Pack
6 pre-filled disposable injection

Rebif 22micrograms/0.5ml

Pack
4 cartridge

Rebif 22micrograms/0.5ml

Pack
6 pre-filled disposable injection
12 pre-filled disposable injection

Rebif 44micrograms/0.5ml

Pack
4 cartridge

Rebif 44micrograms/0.5ml

Pack
12 pre-filled disposable injection

Interferon beta-1b

{ Value = NICE, Index = 0 } { Value = EMC, Index = 3 }

Natalizumab

{ Value = NICE, Index = 0 } { Value = EMC, Index = 3 }

Natalizumab (subcutaneous originator or intravenous biosimilar) can be used as an option to treat highly active relapsing–remitting multiple sclerosis (RRMS) in adults, only if:

  • it has not responded to a full and adequate course of at least 1 disease-modifying therapy OR
  • the characteristics of the person and the activity of their MS mean that cladribine is not suitable. (NICE TA1126)

Natalizumab (intravenous originator) 

  • Should NOT be used to treat highly active RRMS that has not responded to a full and adequate course of at least 1 disease-modifying therapy in adults. (NICE TA1126)

Natalizumab 150mg/1ml solution for injection pre-filled syringes

Pack
2 pre-filled disposable injection

Natalizumab 300mg/15ml solution for infusion vials

Pack
1 vial

Tysabri 150mg/1ml solution for injection pre-filled syringes

Pack
2 pre-filled disposable injection

Tysabri 300mg/15ml concentrate for solution for infusion vials

Pack
1 vial

Ocrelizumab

{ Value = NICE, Index = 0 } { Value = EMC, Index = 3 }

Ofatumumab

{ Value = MHRA Warning Exists, Index = 4 } { Value = NICE, Index = 0 } { Value = EMC, Index = 3 }

Ozanimod

Black Triangle { Value = BLUETEQ, Index = 4 } { Value = NICE, Index = 0 } { Value = EMC, Index = 3 }

Peginterferon beta-1a

{ Value = NICE, Index = 0 } { Value = EMC, Index = 3 }

Ponesimod

{ Value = NICE, Index = 0 } { Value = EMC, Index = 3 }

Siponimod

Black Triangle { Value = NICE, Index = 0 } { Value = EMC, Index = 3 }

Siponimod 250microgram tablets

Pack
12 tablet
120 tablet

Siponimod 2mg tablets

Pack
28 tablet

Teriflunomide

{ Value = NICE, Index = 0 } { Value = EMC, Index = 3 }
Commissioned by NHSE Multiple Sclerosis (relapsing–remitting)

Teriflunomide 7mg tablets

Pack
28 tablet

Teriflunomide 14mg tablets

Pack
28 tablet

Ublituximab

Black Triangle { Value = EMC, Index = 0 } { Value = NICE, Index = 3 }

For treating relapsing forms of multiple sclerosis, defined as active by clinical or imaging features in adults, only if:
 the multiple sclerosis is relapsing–remitting

Ublituximab 150 mg concentrate for solution for infusion

Pack
1 Vial